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Genetically altering protein in colon cancer cells may enhance efficacy of chemotherapy

 2 months ago       29 Views

Colorectal cancer outcomes may improve by genetically altering an immune-regulatory protein in cancer cells, making the cells more vulnerable to chemotherapy. That's according to new Mayo Clinic research.

The findings, published this month in Oncogene, indicate that increasing the expression of the PD-L1 protein in colorectal cancer cells can improve the effectiveness of chemotherapy.

"These findings, if verified by subsequent research, suggest that the level of tumor cell PD-L1 may be important in drug sensitivity and suggest that enhancing PD-L1 expression may be a potential strategy to improve treatment outcomes in this malignancy," says Frank Sinicrope, M.D., a Mayo Clinic medical oncologist and gastroenterologist. Dr. Sinicrope is co-director of the Gastrointestinal Cancer Program at Mayo Clinic and corresponding author of the study.


Author: @DailyCupofYoga

Source: news-medical.net

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