What are the treatment options for Parkinson’s disease?

Medications may help you manage problems with walking, movement and tremor. These medications increase or substitute for dopamine, a specific signaling chemical (neurotransmitter) in your brain.
  • Carbidopa-levodopa. Levodopa, the most effective Parkinson's disease medication, is a natural chemical that passes into your brain and is converted to dopamine. Levodopa is combined with carbidopa, which protects levodopa from premature conversion to dopamine outside your brain, which prevents or lessens side effects such as nausea.
  • Dopamine agonists. Unlike levodopa, dopamine agonists don't change into dopamine. Instead, they mimic dopamine effects in your brain.
  • MAO-B inhibitors help prevent the breakdown of brain dopamine by inhibiting the brain enzyme monoamine oxidase B (MAO-B). This enzyme metabolizes brain dopamine. 
  • Catechol-O-methyltransferase (COMT) inhibitors mildly prolongs the effect of levodopa therapy by blocking an enzyme that breaks down dopamine.
  • Anticholinergics help control the tremor associated with Parkinson's disease. 
  • Amantadine provide short-term relief of symptoms of mild, early-stage Parkinson's disease. It may also be given with carbidopa-levodopa therapy during the later stages of Parkinson's disease to control involuntary movement.
Surgeries that may be performed for Parkinson's disease include:
  • Lesion surgery (burning of tissue) helps control, or stop, the area of the brain that is causing the tremor. 
  • Deep brain stimulation (DBS) sends electrical pulses to your brain and may reduce your Parkinson's disease symptoms.
  • Neural grafting or tissue transplants. Experimental research is being done to find a replacement for the part of the brain that functions improperly in Parkinson's disease.
parkinsons disease treatment

  • "Parkinson's Disease (PD)." Parkinson's Disease (PD) | Johns Hopkins Medicine Health Library. Johns Hopkins Health System, n.d. Web. 05 May 2017.
  • "Parkinson's Disease." Mayo Clinic. Mayo Foundation for Medical Education and Research, 07 July 2015. Web. 05 May 2017.



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