Epilepsy Clinical Trials


Ketogenic Diet Program for Epilepsy

This study will assess the effectiveness of the ketogenic diet (high-fat, low-carbohydrate, and moderate protein) in treating epilepsy. Two study groups will be comprised of children with epilepsy (0-18 years of age) and whether or ...

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The Use of Medicinal Cannabinoids as Adjunctive Treatment for Medically Refractory Epilepsy

Many families of children with medically refractory epilepsy are choosing to use medicinal cannabinoids (MCBD) as an adjunctive alternative treatment option. The safety, tolerability and efficacy of these products are not known. The prim...

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Perampanel for Treatment of Adults With Refractory Focal Epilepsy : a Pilot Study.

The goal of the present study is to evaluate ("screen") a large number (12) of different dual therapies of perampanel + another AED ("PMP+") for a large, 75-100% seizure frequency reduction. The design of the study will differ ...

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Cerebral Oxygen Saturation and Cytochrome Oxidase REDOX State in Children With Epilepsy: A Pilot Study

The purpose of this pilot study is to describe the relationship of regional cerebral oximetry and cytoximetry, measured using near-infrared spectroscopy, with seizure activity in the periictal period in children with epilepsy.  

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Modulating Movement Intention

Conditions:   Seizures;   Seizure Disorder;   Psychogenic Movement Disorder
Interventions:   Device: Sham TMS3 stimulation;   Device: rTMS of left or right angular gyrus (AG) or frontal cortex (FC);   Device: Anodal tDCS of left or right AG or FC
Sponsor:   New York University School of Medicine
Recruiting - verified July 2017

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Acoustic Stimulation for Seizure Suppression

Condition:   Epilepsy
Interventions:   Other: Acoustic 1Hz Stimulation;   Other: Sham Background Noise
Sponsor:   New York University School of Medicine
Not yet recruiting - verified July 2017

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A Drug Study to Determine the Long-term Safety and Tolerability in Children and Adolescents (4-17 Years in Age) Taking the Drug

Condition:   Epilepsy
Intervention:   Drug: Eslicarbazepine acetate
Sponsor:   Sunovion
Recruiting - verified July 2017

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A Study to Assess the Efficacy and Safety of Brivaracetam as Treatment for Increased Seizure Activity in an Epilepsy Monitoring Unit Setting

Condition:   Epilepsy
Interventions:   Drug: Brivaracetam;   Drug: Lorazepam
Sponsor:   UCB Biopharma S.P.R.L.
Recruiting - verified July 2017

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Prompt Diagnosis and Treatment of Subclinical Seizures After Cardiac Arrest

Conditions:   Heart Arrest;   Seizures
Intervention:   Procedure: DSA EEG
Sponsors:   Children's Hospital of Philadelphia;   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 2017

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Brain P-gp and Inflammation in People With Epilepsy

Condition:   Epilepsies, Partial
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 10, 2017

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Surgery as a Treatment for Medically Intractable Epilepsy

Conditions:   Epilepsy;   Epilepsy, Temporal Lobe;   Partial Epilepsy
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 14, 2017

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Neurobiology of Psychogenic Movement Disorder and Non-Epileptic Seizures

Conditions:   Psycogenic Movement Disorders;   Non-epileptic Seizures
Intervention:  
Sponsor:   National Institute of Neurological Disorders and Stroke (NINDS)
Recruiting - verified July 21, 2017

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Study to Evaluate the Efficacy and Safety of Perampanel as Monotherapy or First Adjunctive Therapy in Subjects With Partial Onset Seizures With or Without Secondarily Generalized Seizures or With Primary Generalized Tonic-Clonic Seizures

Conditions:   Partial Onset Seizures;   Secondarily Generalized Seizures;   Primary Generalized Tonic-Clonic Seizures
Intervention:   Drug: Perampanel
Sponsor:   Eisai Inc.
Recruiting - verified September 2017

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Study of TAK-935 as an Adjunctive Therapy in Participants With Developmental and/or Epileptic Encephalopathies

Condition:   Developmental and/or Epileptic Encephalopathies
Interventions:   Drug: TAK-935;   Drug: Placebo
Sponsors:   Takeda;   Ovid Therapeutics
Recruiting - verified September 2017

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