What causes Crohn’s disease?

There is no exact cause of Crohn's disease. Various stimuli may trigger Crohn's disease, affecting individuals differently. For instance, it may be that a virus or bacteria, something the intestines, or even your family history. Scientists believe it is a combination of all these factors. 
 
 
Autoimmune reaction 
When your immune system attacks healthy cells in your body. The immune system may create an abnormal inflammation reaction in the intestinal wall that does not stop. This makes the immune system more susceptible to a virus or bacterium which may trigger Crohn's disease. When your immune system tries to fight off the invading microorganism, an abnormal immune response causes the immune system to attack the cells in the digestive tract, too. 
 
 
 
Genes
Crohn's is more common in people who have family members with the disease, so genes may play a role in making people more susceptible. However, most people with Crohn's disease don't have a family history of the disease. If you have Crohn’s disease, you may have inherited a unique gene in your immune system. Then, something happened that triggered that gene, causing an overreaction, which then cause inflammation in your intestines.
 
 
 
Other factors
 
  • Smoking
  • Nonsteroidal anti-inflammatory drugs (NSAIDs) 
  • A high-fat diet
 
 
crohn's disease causes
 
 

Sources
  • "Crohn's Disease | NIDDK." National Institutes of Health. U.S. Department of Health and Human Services, n.d. Web. 23 Apr. 2017.
  • Crohn's Disease." Crohn's Disease | Johns Hopkins Medicine Health Library. Johns Hopkins Medicine Health Library, n.d. Web. 23 Apr. 2017.
  • "Crohn's Disease." Mayo Clinic. Mayo Foundation for Medical Education and Research, 14 Aug. 2014. Web. 23 Apr. 2017

 

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