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What is pentosan polysulphate sodium (PPS) and why are AFL players using it?

 1 year ago       128 Views

(MENAFN - The Conversation) AFL players are reportedly being treated with injections of the drug pentosan polysulphate sodium (PPS) for knee and bone pain.

Up to 50 current and former AFL players are reported to have been given PPS over the past few months, under the Therapeutic Goods Administration's special access scheme .

In Australia, PPS is available only by prescription, under the brand name Elmiron, for the treatment of interstitial cystitis, a type of chronic inflammation of the bladder wall.

Other uses The Australian pharmaceutical company Paradigm Biopharma is looking to repurpose PPS as a treatment for pain in people with osteoarthritis of the knee and lesions in the subchondral bone – the layer of bone just below the cartilage in joints which acts as a so-called 'shock-absorber'.

The company is currently conducting a randomised, placebo-controlled clinical trial in Australia using an injectable form of the drug.

By controlling the lesions, the drug prevents the pain.

AFL player treatment Arthritis and joint pain are common injuries among elite sports people.

PPS is administered as an injection to the players twice a week for a period of six weeks and results have indicated that PPS works well to control their knee pain.

Before routine prescribing of PPS for people with knee pain and bone lesions, the clinical trial must show the drug is safe in its injectable form and that any reduction is pain is at least as good as current treatments.

AFL Doping Therapeutic Goods Administration special access scheme blood clotting Knee injury

Author: @DailyCupofYoga


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