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Study reveals safety, efficacy of brexpiprazole for schizophrenia patients with severe psychotic symptoms

 5 months ago       105 Views

Otsuka Pharmaceutical Co., Ltd. (Otsuka) and H. Lundbeck A/S (Lundbeck) announced study results on the safety and efficacy of brexpiprazole in the treatment of patients with schizophrenia experiencing severe psychotic symptoms during an acute episode.

The data will be presented at the upcoming Psych Congress, held in Orlando from October 25-28, 2018.

The post hoc, pooled analysis focused on three short-term studies, Vector [NCT01396421], Beacon [NCT01393613], and Lighthouse [NCT01810380], evaluating brexpiprazole in subgroups of patients with severe psychotic symptoms.

Patients with severe psychotic symptoms were specified by having PANSS total scores of greater than 95, which was the median score of the full patient population at baseline.

The 681 patients included in the analysis exhibited an average baseline PANSS total score of 106 with 427 patients given a dose of 2-4 mg of brexpiprazole and 254 given placebo.

The study demonstrated that patients receiving brexpiprazole showed a mean improvement in PANSS Total score of 24.03 vs. 17.27 for patients receiving placebo (placebo-adjusted difference of 6.76, p


Author: @DailyCupofYoga

Source: news-medical.net

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