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Resynchronizing Neurons to Erase Schizophrenia

 1 year ago       103 Views

Summary: Researchers report that by increasing the excitability of a subpopulation of hippocampal inhibitory neurons, certain behavioral symptoms associated with schizophrenia can be suppressed.

While research over the past few years has suggested that desynchronization of neurons may be the cause of its neuropsychiatric symptoms, such as memory disorders, hyperactivity or hallucinatory phenomena, the cellular origin of such desynchronization remains poorly understood.

They studied a mouse model that reproduces the genetic alteration of DiGeorge syndrome as well as some behavioural changes associated with schizophrenia.

“The organization and synchronization of neural networks is achieved through the intervention of subpopulations of inhibitory neurons, including parvalbumin neurons,» says Carleton.

“However, in this animal model of schizophrenia, these neurons are much less active.

” Restoring neural order, even in adulthood The second step was to try to restore the synchronization necessary for neural networks to function properly.

According to our results, reinforcing the action of a poorly active inhibitory neuron, even after the brain has developed, could be sufficient to restore the proper functioning of these neural networks, thus making certain pathological behaviours disappear.” Current treatments for schizophrenia are primarily based on the administration of antipsychotic drugs targeting the dopaminergic and serotoninergic systems.

The neuroscientists now want to confirm their results by extending their research to schizophrenia resulting from genetic alterations different from those of DiGeorge syndrome.

Source: Alan Carleton – University of Geneva Publisher: Organized by

Published September 17 2018. doi:10.1038/s41593-018-0225-y Abstract Restoring wild-type-like CA1 network dynamics and behavior during adulthood in a mouse model of schizophrenia Schizophrenia is a severely debilitating neurodevelopmental disorder.

Author: @DailyCupofYoga


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