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Ketamine's role in treatment of depression: Study

 12 months ago       144 Views

A new study has explored the actual workings of ketamine in depression and found that the drug can act on the same receptors as opioid pain relievers.

These cases were all of treatment-resistant depression.

In addition some were administered naltrexone and others normal saline infusion.

Naltrexone is a drug that can block the effects of opioids.

Results showed that those on ketamine and saline combination found relief from their depressive symptoms quickly compared to those on ketamine and naltrexone combination.

The initial trial plan was to include 30 patients.

Glutamate is an important neurotransmitter in the brain.

Many researchers have thought that glutamate could be the key zone where ketamine acts as an antidepressant.

Co-senior study author Dr. Alan Schatzberg, a professor of psychiatry and behavioral sciences at Stanford explained that the ketamine was not working as “everyone thought it was working.” Heifets noted that ketamine is a drug of abuse (called “Special K” in party circuits) that has been in use for a long time and there is an abuse potential of this drug acting on the opioid receptors to provide such effects.

However the whole team agrees that this new study shows how ketamine can help patients who have intractable depression.

Author: @DailyCupofYoga


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