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How Alcohol Mutates Stem Cells And Damages Chromosomes

 2 years ago       296 Views

New research shows how alcohol damages DNA in stem cells, helping to explain why drinking increases your risk of cancer.

But in this study, researchers have used mice to show how alcohol exposure leads to permanent genetic damage.

They then used chromosome analysis and DNA sequencing to examine the genetic damage caused by acetaldehyde, a harmful chemical produced when the body processes alcohol.

7 Types Of Cancer It is important to understand how the DNA blueprint within stem cells is damaged because when healthy stem cells become faulty, they can give rise to cancer.

Professor Ketan Patel, lead author of the study and scientist, part funded by Cancer Research UK, at the MRC Laboratory of Molecular Biology, said: “Some cancers develop due to DNA damage in stem cells.

So, when they drink, acetaldehyde builds up which causes a flushed complexion, and also leads to them feeling unwell.

DNA Damage In the study, when mice lacking the critical ALDH enzyme – ALDH2 – were given alcohol, it resulted in four times as much DNA damage in their cells compared to mice with the fully functioning ALDH2 enzyme.

The second line of defence used by cells is a variety of DNA repair systems which, most of the time, allow them to fix and reverse different types of DNA damage.

But it’s important to remember that alcohol clearance and DNA repair systems are not perfect and alcohol can still cause cancer in different ways, even in people whose defence mechanisms are intact.” The research was funded by Cancer Research UK, Wellcome and the Medical Research Council.

Juan I. Garaycoechea, Gerry P. Crossan, Frédéric Langevin, Lee Mulderrig, Sandra Louzada, Fentang Yang, Guillaume Guilbaud, Naomi Park, Sophie Roerink, Serena Nik-Zainal, Michael R. Stratton & Ketan J. Patel Alcohol and endogenous aldehydes damage chromosomes and mutate stem cells Nature; doi:10.1038/nature25154


Author: @DailyCupofYoga

Source: reliawire.com

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