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Disrupted Networks Link Overlapping Cognitive Deficits in Psychiatric Disorder

 8 months ago       135 Views

Psychiatric disorders share common alterations of functional connectivity between three core brain networks involved in cognition, according to a meta-analysis published in Biological Psychiatry.

The study suggests that the alterations in these networks contribute to the cognitive dysfunction present in multiple psychiatric disorders.

The alterations in functional connectivity, which emerged from a meta-analysis of 242 functional brain imaging studies in people with a variety of psychiatric disorders, were found in the three large-scale networks considered to be particularly important for complex cognition–the default mode network; frontoparietal network; and the salience network.

Further, analysis of 363 structural brain imaging studies revealed reduced gray matter that was confined to the altered networks, tightly linking structural and functional alterations.

Importantly, the study provides the first evidence from a meta-analysis of common functional connectivity alterations in neurocognitive networks across psychiatric disorders.

Although enormous progress has been made in characterizing the neural correlates of diagnoses and symptoms over the past 25 years, neuroimaging biomarkers have yet to contribute to the psychiatric diagnostic process.

Image Source: image is in the public domain.

Published January 3 2019. doi:10.1016/j.biopsych.2018.11.011 Abstract Common Dysfunction of Large-Scale Neurocognitive Networks Across Psychiatric Disorders Background Cognitive dysfunction is one of the most prominent characteristics of psychiatric disorders.

The aim of this study was to investigate functional connectivity and structural perturbations across psychiatric diagnoses in three neurocognitive networks of interest: the default mode network (DMN), the frontoparietal network (FPN), and the salience network (SN).

Results We found that the three neurocognitive networks of interest were characterized by shared alterations of functional connectivity architecture across psychiatric disorders.

Author: @DailyCupofYoga


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