What causes chronic myelogenous leukemia (CML)?

There is no exact cause for CML, however it is known that most patients’ white blood cells, called granulocytes, somehow develop changes (mutations) in their DNA called the Philadelphia chromosome, where chromosomes 9 and 22 are fused together. The Philadelphia chromosome overproduces an enzyme called tyrosine kinase, causing the bone marrow to make too many white blood cells. These mutated cells eventually grow in abundance and leave little or no room for healthy (red or white) blood cells and platelets. The overproduction causes many complications and interferes with normal blood cell production and function. 
chronic myelogenous leukemia causes

  • "Chronic Myelogenous Leukemia." Mayo Clinic. Mayo Foundation for Medical Education and Research, 26 May 2016. Web. 07 July 2017.
  • "Chronic Myelogenous Leukemia." Chronic Myelogenous Leukemia. Cleveland Clinic, n.d. Web. 07 July 2017.
  • Hill, Michael. "Chronic Myelogenous Leukemia." Johns Hopkins Sidney Kimmel Comprehensive Cancer Center. Johns Hopkins Health System, 04 Feb. 2016. Web. 07 July 2017.



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