What causes chronic fatigue syndrome?

The exact cause of CFS is unknown, however, it may be a combination of factors that affect the people who were born with a predisposition for the disorder. Some of the factors include:
  • Viral infections. Some patients develop chronic fatigue syndrome after having a viral infection, thus may be a possible trigger to the disorder. 
  • Immune system problems. The immune systems appear to be slightly impaired in patients who have chronic fatigue syndrome. 
  • Hormonal imbalances. Patients chronic fatigue syndrome may also experience abnormal blood levels of hormones produced in the hypothalamus, pituitary glands or adrenal glands. 
  • Changes in important neurotransmitters. Some patients with CFS have abnormally high levels of serotonin and deficiencies of dopamine, an important neurotransmitter associated with feelings of reward, or imbalances between the neurotransmitters norepinephrine and dopamine. 
  • Stress hormone deficiencies. Most CFS patients have lower levels of cortisol, a stress hormone, which can cause an impaired response to psychological or physical stresses, such as infection or exercise.
  • Allergies. Allergies, like viral infections, may trigger a cascade of immune abnormalities that lead to CFS. 


chronic fatigue syndrome (CFS) causes


  • "Chronic Fatigue Syndrome." Mayo Clinic. Mayo Foundation for Medical Education and Research, 30 Aug. 2016. Web. 14 June 2017.
  • "Chronic Fatigue Syndrome." Chronic Fatigue Syndrome | Johns Hopkins Medicine Health Library. Johns Hopkins Health System, n.d. Web. 14 June 2017.
  • "Chronic Fatigue Syndrome." University of Maryland Medical Center. University of Maryland Medical Center (UMMC), 07 Feb. 2012. Web. 14 June 2017.



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