What causes acute lymphoblastic leukemia (ALL)?

The exact cause of ALL is not well known. It stems from alterations in the DNA of bone marrow cells. These alterations cause the bone marrow to continue producing immature white blood cells, that develop into abnormal cancer cells (lymphoblasts). These abnormal cells rapidly outnumber the normal healthy cells and can spread to other parts of the body. DNA alterations that typically cause cancers affect oncogenes or tumor suppressor genes. Oncogenes help cells multiply, while tumor suppressor genes help to reduce cell production. Therefore, DNA alterations that activate oncogenes or suppress tumor suppressor genes can be responsible for the development of ALL. The exact cause of these DNA alterations is still unknown. 
acute lymphoblastic leukemia (ALL) causes

  • "Acute lymphocytic leukemia." Mayo Clinic. Mayo Foundation for Medical Education and Research, 28 Jan. 2016. Web. 28 Jul. 2017.
  • “Do We Know What Causes Acute Lymphocytic Leukemia?” American Cancer Society, 2 Dec. 2014. Web. 28 Jul. 2017.



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